Roma’s Edoardo Bove was hit by a beer bottle thrown by the crowd as his side lost to arch-rivals Lazio in a heated Coppa Italia quarter-final that ended with three red cards.

Mattia Zaccagni scored the only goal.

Lazio’s Pedro and Roma’s Sardar Azmoun were dismissed in injury time, with Gianluca Mancini, also of Roma, sent off after the final whistle.

Zaccagni’s winner was from a penalty awarded by the video assistant referee for a foul by Dean Huijsen on Valentin Castellanos.

Roma boss Jose Mourinho has lost four of his six derbies since taking charge in 2021.

“It’s always painful to lose, doubly so in the derby,” he told Mediaset.

“It’s a modern football penalty, the sort that wouldn’t have been given before VAR. The referee didn’t give it when he was three metres away but with VAR he then gives it.”

Lazio will play Juventus or Frosinone in the semi-finals.

Meanwhile, Atalanta beat AC Milan 2-1 thanks to two goals from Teun Koopmeiners to set up a semi-final clash with Fiorentina, who saw off Bologna 5-4 on penalties after a goalless draw on Tuesday.