Fixtures will continue taking place as long as it is safe to do so, but the EFL is implementing mandatory testing across all its member clubs this week following a spate of postponements during the festive programme.
Of the 52 fixtures called off so far this season because of Covid-19, 34 of them have been in League One.
“My fear, in common with that of a number of other League One chief executives I spoke to on Friday, is that there will be so many players test positive that we’ll almost have to suspend the season,” Bottomley continued.
“Human life is far more important than whether we play football matches, surely.
“I’m talking from personal experience. My 85-year-old mother has tested positive and has been in hospital from the beginning of December with Covid. It’s best football takes a break and step back.”